Uw cse 490 b1 04 matlab functions and enzyme kinetics. This kinetic model is relevant to situations where very simple kinetics can be assumed, i. Biochemical reactions in living cells are often catalyzed by enzymes. It is named after leonor michaelis and maud menten. Use differential equations, mass action kinetics, or michaelis menten kinetics to define enzyme reactions. However, it will be very helpful if you are comfortable with the material in introductory biology 7. In addition, each weekly problem set will have a computational problem, so prior experience with a computational package such as matlab, mathematica, or python is expected. Matlab functions with application to mechaelismenton kinetics. Part 1 demonstrates how to translate a catalytic mechanism into a system of ordinary differential equations. These enzymes are proteins that bind and subsequently react specifically with.
Vmax is the maximum enzyme velocity in the same units as y. A simple tutorial on mathematical modeling and simulation of biochemical reaction kinetics. Part 2 demonstrates how to build and simulate a kinetic model using matlab. After entering data, click analyze, choose nonlinear regression, choose the panel of enzyme kinetics equations, and choose michaelismenten enzyme kinetics. The goal of this chapter is to develop the mathematical techniques to quantitatively model biochemical reactions. Enzymes part 2 of 5 enzyme kinetics and the michaelis menten model. Simple model for single substrate catalyzed reactions. Michaelis menten kinetics approximately describes the kinetics of many enzymes. Solve differential equations in matlab and simulink. A simple model for enzymecatalyzed reactions starts a substrate s reversibly binding with an enzyme e.1094 697 1277 924 560 267 741 632 778 492 1179 566 675 1134 619 245 1305 635 1134 532 453 367 272 528 1512 1468 343 1616 133 882 1402 612 1309 1418 952 1120 1391 873 1363 245 1157